Because of the kidney’s high blood flow, its ability to concentrate chemicals, and the presence of renal XMEs, the kidney may also be a site of toxicity from xenobiotics. Several studies have reported activity of known FMO substrates by brain microsomes (Bhamre et al., 1993; Duffel and Gillespie, 1984; Kawaji et al., 1994), and one form of FMO has been demonstrated using polymerase chain reaction amplification (Blake et al., 1996). Find out what these mean to get familiar with the different abbreviated names for various operations, lines of business, and programs. 1995). Recent studies have identified five forms of FMO (FMO1–FMO5), which are differentially expressed with respect to species and tissue.33,34 FMO2, for example, is expressed in the lung but not the liver. Acronym Definition; FMOS: Factory Mars Operating System: FMOS: Full Moon O Sagashite (anime): FMOS: First Marshal on Scene (motorsports safety training; … new search; suggest new definition; Search for FOB in Online Dictionary Encyclopedia For FMO we have found 164 definitions. Definition of FO2 in Science & Medicine. Such FMO3 variants may have evolved to decrease metabolism of odorous trimethylamine (TMA), so that TMA could be used as a primitive volatile insecticide (Cashman and Zhang 2006; Cashman et al. The gene view histogram is a graphical view of mutations across FMO2. Boland et al. As with P450, FMO isoforms are ubiquitously distributed in the animal kingdom and in the body where the highest concentrations are generally found in the liver, although certain species have high enzyme concentrations in the lung (rabbit) and kidney (mouse). Other studies have shown the existence of an FMO form now known as FMO2 in the lung that is not present in the liver (Lawton et al., 1990; Tynes and Hodgson, 1983; Tynes et al., 1985; Venkatesh et al., 1992b; Williams et al., 1984, 1985). Browse and search thousands of Abbreviations that start with F in our comprehensive reference resource. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Progress in Molecular Biology and Translational Science, Biotransformation (Metabolism) of Pesticides, Pesticide Biotransformation and Disposition, Bond, 1983, 1993; Dahl and Lewis, 1993; Ding and Kamienski, 2003, Kinsler et al., 1988; Tynes and Hodgson, 1983, 1985a,b, ). FMO2. These are FAD-containing enzymes that, like the CYPs, are localized in the endoplasmic reticulum (ER). The FMO3 360P SNP could contribute to greater metabolism of FMO-mediated metabolism and possibly greater drug clearance in individuals possessing this SNP. As described below, some of these FMO variants modulate drug or chemical metabolism in vivo. showing only Science & Medicine definitions (show all 78 definitions). In addition, CYP1A1 shows higher expression in lung than in liver and kidney. The visualization of the basal gene expression in the investigated tissue samples of the meta pathway for biotransformation shows a clearly higher expression of most biotransformation-related CYP genes in liver. FM03 is important in the metabolism of several pharmaceuticals and xenobiotics including the chemotherapeutic drug dasatinib.47 FMO1, FMO2, and FMO3 have relatively broad substrate specificity. Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen; Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Find out what is the full meaning of FMOG on Abbreviations.com! Jennen, ... Jos C.S. For kidney, two distinct anatomical regions were used because these showed unique and highly distinctive patterns of gene expression [42]. Search and view thousands of Medical Abbreviations and Acronyms. These Gene Atlas basal expression profiles are displayed for 79 human tissue samples per single gene present on the Affymetrix Human Genome U133A GeneChip array. FMOs are gene products of a gene family, and the isoforms are denoted simply by Arabic numerals, for example, FMO1, FMO2, and so on. In general, the use of abbreviations should be limited to this list. This has not been observed for FMO3 but SNPs in the promoter region have been associated with an 8-fold increase in promoter activity [42]. To date, most FMO splice variants either caused a frame-shift or lacked essential functional sites and were not capable of encoding a functional enzyme. Methimazole, sulindac sulfide, and cimetidine appear to be subject to FMO-mediated S-oxygenation. HMO: [ helth ] a relative state in which one is able to function well physically, mentally, socially, and spiritually in order to express the full range of one's unique potentialities within the environment in which one is living. Because the skin is the largest organ in the human body, is continuous over the surface area of the body, and is in direct contact with the environment, it is often the portal of entry for pesticides and other xenobiotics. The activation or detoxication of pesticides by the CNS is of particular interest in the case of pesticides that both exhibit their action and are metabolized in the brain.
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